含SH2结构域接头蛋白B抗体
规格：1mg/1ml
英文名： SHB
别名： bA3J10.2; OTTHUMP00000021397; RP11 3J10.8; RP113J10.8; SH2 domain containing adapter protein B; SH2 domain-containing adapter protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB a
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SHB
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
含SH2结构域接头蛋白B抗体产品介绍：Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Subunit: Interacts with PTPN11 (By similarity). Subcellular Location: Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation. Tissue 含SH2结构域接头蛋白B抗体Specificity: Widely expressed. Post-translational modifications: Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. Similarity: Contains 1 SH2 domain. Gene ID: 6461 Database links: Entrez Gene: 538275 Cow Entrez Gene: 481619 Dog Entrez Gene: 6461 Human Entrez Gene: 230126 Mouse Entrez Gene: 362513 Rat Omim: 600314 Human SwissProt: Q15464 Human 含SH2结构域接头蛋白B抗体SwissProt: Q6PD21 Mouse Unigene: 521482 Human Unigene: 251716 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
含SH2结构域接头蛋白B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid