SH3结构域结合蛋白2抗体
规格：1mg/1ml
英文名： SH3BP2
别名： 3BP-2; 3BP2; 3BP2_HUMAN; Abl SH3 binding protein 2; Cherubism; CRBM; CRPM; FLJ42079; FLJ54978; RES4-23; SH3 domain binding protein 2; SH3 domain-binding protein 2; Sh3bp2; TNFAIP3 interacting protein
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SH3BP2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞浆
SH3结构域结合蛋白2抗体产品介绍：background: The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Function: Binds differentially to the SH3 domains of certain proteins of signal transduction SH3结构域结合蛋白2抗体pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. Tissue Specificity: Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Post-translational modifications: Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity). DISEASE: Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by SH3结构域结合蛋白2抗体excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling. Similarity: Contains 1 PH domain. Contains 1 SH2 domain. Gene ID: 6452 Database links: Entrez Gene: 6452 Human Entrez Gene: 24055 Mouse Entrez Gene: 305450 Rat Omim: 602104 Human SwissProt: P78314 Human SwissProt: Q06649 Mouse Unigene: 167679 Human Unigene: 5012 Mouse Unigene: 212791 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SH3结构域结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid