脂蛋白脂酶抗体
规格：1mg/1ml
英文名： Lipoprotein lipase
别名： Lipoprotein lipase; LIPD; LIPL_HUMAN; LPL; LPL protein; EC 3.1.1; EC 3.1.1.34; HDLCQ11; LPL; LPL protein; MGC137861.
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LPL
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞浆 细胞膜 分泌型蛋白
脂蛋白脂酶抗体产品介绍：background: Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation. Function: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Subunit: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated 脂蛋白脂酶抗体endocytic vesicles. Tissue Specificity: Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells. Post-translational modifications: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. DISEASE: Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia 脂蛋白脂酶抗体retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Similarity: Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain. Gene ID: 4023 Database links: Entrez Gene: 280843 Cow Entrez Gene: 4023 Human Entrez Gene: 16956 Mouse Omim: 238600 Human SwissProt: P11151 Cow SwissProt: P06858 Human SwissProt: P11152 Mouse Unigene: 180878 Human Unigene: 1514 Mouse Important Note: This 脂蛋白脂酶抗体product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脂蛋白脂酶（lipoprteinlipase，LPL）是甘油三酯降解为甘油和游离脂肪酸 (FFA)反应的限速酶,是脂肪细胞、心肌细胞、骨骼肌细胞、乳腺细胞以及巨噬细胞等实质细胞合成和分泌的一种糖蛋白与机体的脂质代谢及肥胖与否密切相关. 近年来研究认为：LPL可通过粘附作用，促进了单核细胞血管内皮细胞及肿瘤坏死因子（TNF）的分泌、血管平滑肌细胞增殖等因素，导致动脉粥样硬化的加重。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid