GTP酶激活蛋白样RASA4抗体
规格：1mg/1ml
英文名： RASA4
别名： Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; RASL2_HUMAN; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activat
分子量： 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RASA4
交叉反应：Human, Mouse,
细胞定位：细胞浆
GTP酶激活蛋白样RASA4抗体产品介绍：background: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as GTP酶激活蛋白样RASA4抗体an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Subcellular Location: Cytoplasm; cytosol. Cell membrane; peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane. Tissue Specificity: Widely expressed. Similarity: Contains 1 Ras-GAP domain. Gene ID: 10156 Database links: Entrez Gene: 10156 Human Entrez Gene: 54153 Mouse Entrez Gene: 288589GTP酶激活蛋白样RASA4抗体 Rat Omim: 607943 Human SwissProt: O43374 Human SwissProt: Q6PFQ7 Mouse Unigene: 696339 Human Unigene: 290655 Mouse Unigene: 1366 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GTP酶激活蛋白样RASA4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid