激肽释放酶4抗体
规格：1mg/1ml
英文名： KLK4
别名： Kallikrein 4; 7S nerve growth factor alpha chain; AI2A1; Alpha-NGF; Androgen-regulated message 1; ARM1; EC 3.4.21.-; EMSP 1; EMSP; EMSP1; Enamel Matrix Serine Protease 1; Enamel matrix serine proteina
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KLK4
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：分泌型蛋白
激肽释放酶4抗体产品介绍：background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq]. Subcellular Location: Secreted. Tissue Specificity: Expressed in prostate. DISEASE: Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary 激肽释放酶4抗体and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown激肽释放酶4抗体 pigment is present in middle layers of enamel. Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. Gene ID: 9622 Database links: Entrez Gene: 9622 Human Entrez Gene: 56640 Mouse Omim: 603767 Human SwissProt: Q9Y5K2 Human SwissProt: P00757 Mouse Unigene: 218366 Human Unigene: 42080 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. KLK4目前认为是前列腺癌等其他肿瘤很有意义的标志物。激肽释放酶KLK是激肽系统的主要限速酶，它是一组存在于多数组织和体液中的丝氨酸蛋白酶，是一种肽链内切酶。KLK又称血管舒缓素，包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽，可裂解激肽原释放具有活性的激肽，由激肽发挥对心血管系统及肾脏功能的调节作用。 组织KLK是一个大的基因家族，主要分布在肺、肾、血管、脑、肾上腺组织，为一种中等大小的糖蛋白。
产品应用：激肽释放酶4抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid