胰岛细胞自身抗原相关蛋白PTPRN2抗体
规格：1mg/1ml
英文名： PTPRN2
别名： IA 2beta; IA2beta; IAR; IAR/receptor like protein tyrosine phosphatase; ICAAR; Islet cell autoantigen related protein; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase rec
分子量： 109kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPRN2
交叉反应：Human,
细胞定位：细胞膜
胰岛细胞自身抗原相关蛋白PTPRN2抗体产品介绍：background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Function: Implicated in development胰岛细胞自身抗原相关蛋白PTPRN2抗体 of nervous system and pancreatic endocrine cells. Subcellular Location: Membrane. Tissue Specificity: Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord. Post-translational modifications: Appears to undergo multiple proteolytic cleavage at consecutive basic residues. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 5799 Database links: Entrez Gene: 5799 Human Entrez Gene: 19276 Mouse Entrez Gene: 29714 Rat Omim: 601698 Human SwissProt: Q92932 Human SwissProt: P80560 Mouse SwissProt: Q63475 Rat Unigene: 490789 Human Unigene: 胰岛细胞自身抗原相关蛋白PTPRN2抗体206054 Mouse Unigene: 11044 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰岛细胞自身抗原相关蛋白PTPRN2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid