蛋白酶激活复合物亚基2抗体
规格：1mg/1ml
英文名： PSME2
别名： 11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSME2
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞浆
蛋白酶激活复合物亚基2抗体产品介绍：background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.蛋白酶激活复合物亚基2抗体 [provided by RefSeq, Jul 2008] Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Subunit: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. Similarity: Belongs to the PA28 family. Gene ID: 5721 Database links: Entrez Gene: 5721 Human Entrez Gene: 509857 Cow Entrez Gene: 480258 Dog Entrez Gene: 101836765 Hamster Entrez Gene: 100051729 Horse Entrez Gene:蛋白酶激活复合物亚基2抗体 19188 Mouse Entrez Gene: 397522 Pig Entrez Gene: 100362709 Rat Entrez Gene: 100364216 Rat Entrez Gene: 29614 Rat Entrez Gene: 30647 Zebrafish Omim: 602161 Human SwissProt: Q5E9G3 Cow SwissProt: Q9UL46 Human SwissProt: P97372 Mouse SwissProt: Q863Z0 Pig SwissProt: Q63798 Rat Unigene: 434081 Human Unigene: 512410 Human Unigene: 371573 Mouse Unigene: 127779 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酶激活复合物亚基2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid