磷酸化核仁蛋白C23抗体
规格：1mg/1ml
英文名： phospho-Nucleolin (Thr76)
别名： Nucleolin (phospho T76); p-Nucleolin (phospho T76); C23; FLJ45706; MS1116; NCL; Nucl; NUCL_HUMAN; Nucleolin; Protein C23.
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Cow,
细胞定位：细胞核
磷酸化核仁蛋白C23抗体产品介绍：background: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly 磷酸化核仁蛋白C23抗体than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Subcellular Location: Nucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Post-translational modifications: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Similarity: Contains 4 RRM (RNA recognition motif) domains. Gene ID: 4691 Database links: Entrez Gene: 4691 Human Entrez Gene: 17975 Mouse Entrez Gene: 25135 Rat 磷酸化核仁蛋白C23抗体Omim: 164035 Human SwissProt: P19338 Human SwissProt: P09405 Mouse SwissProt: P13383 Rat Unigene: 79110 Human Unigene: 154378 Mouse Unigene: 474153 Mouse Unigene: 144561 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化核仁蛋白C23抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid