信号通路Wnt5a抗体
规格：1mg/1ml
英文名： WNT5A
别名： wingless-related MMTV integration site 5A; hWNT 5A; hWNT5A; Protein Wnt 5a; Protein Wnt5a; Wingless type MMTV integration site family member 5A; Wnt-5a; WNT 5A protein precursor; WNT5A protein precurs
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WNT5A
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞外基质 分泌型蛋白
信号通路Wnt5a抗体产品介绍：background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases 信号通路Wnt5a抗体proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Subunit: Interacts with PORCN. Interacts with WLS. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). Post-translational modifications: Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding. Glycosylation is necessary for secretion but not for activity. DISEASE: Defects in WNT5A are the cause of Robinow syndrome autosomal dominant (DRS) [MIM:180700].信号通路Wnt5a抗体 A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. Similarity: Belongs to the Wnt family. Gene ID: 7474 Database links: Entrez Gene: 7474 Human Entrez Gene: 530005 Cow Entrez Gene: 22418 Mouse Entrez Gene: 64566 Rat Omim: 164975 Human SwissProt: P41221 Human SwissProt: P22725 Mouse SwissProt: Q5PY99 Rat SwissProt: Q9QXQ7 Rat Unigene: 643085 Human Unigene: 287544 Mouse Unigene: 48749 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. WNT5A蛋白属于Wnt原癌基因家族中的一种。Wnt5a与肿瘤、发生、转移有关。
信号通路Wnt5a抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid