组蛋白赖氨酸N-甲基NSD3抗体
规格：1mg/1ml
英文名： NSD3
别名： DKFZp667H044; FLJ20353; Histone lysine N methyltransferase NSD3; Histone-lysine N-methyltransferase NSD3; MGC126766; MGC142029; NSD 3; NSD3_HUMAN; Nuclear set domain containing 3; Nuclear SET domain c
分子量： 162kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NSD3
交叉反应：Human,
细胞定位：细胞核
组蛋白赖氨酸N-甲基NSD3抗体产品介绍：background: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. [provided by RefSeq, Jul 2008] Function: Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Subunit: Interacts with BRD4. Subcellular Location: Nucleus. Chromosome. Tissue Specificity: Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. DISEASE: Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC).组蛋白赖氨酸N-甲基NSD3抗体 Amplified or overexpressed in NSCLC. A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 4 PHD-type zinc fingers. Contains 1 post-SET domain. 组蛋白赖氨酸N-甲基NSD3抗体Contains 2 PWWP domains. Contains 1 SET domain. Gene ID: 54904 Database links: Entrez Gene: 54904 Human Entrez Gene: 234135 Mouse Entrez Gene: 290831 Rat Omim: 607083 Human SwissProt: Q9BZ95 Human SwissProt: Q6P2L6 Mouse Unigene: 608111 Human Unigene: 217337 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白赖氨酸N-甲基NSD3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid