WRCH1抗体
规格：1mg/1ml
英文名： WRCH1
别名： WRCH-1; WRCH 1; Wnt-1 responsive Cdc42 homolog 1; Rho-related GTP-binding protein RhoU; Ryu GTPase; CDC42-like GTPase 1; Rho GTPase-like protein ARHU; GTP-binding protein-like 1; RHOU; SB128; ARHU; CD
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WRCH-1
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞浆 细胞膜
WRCH1抗体产品介绍：background: The WRCH1 protein is a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Subunit: Interacts with PAK3. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. WRCH1抗体Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells. Tissue Specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. Post-translational modifications: Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. WRCH1抗体Similarity: Belongs to the small GTPase superfamily. Rho family. Gene ID: 58480 Database links: Entrez Gene: 58480 Human Entrez Gene: 69581 Mouse Omim: 606366 Human SwissProt: Q7L0Q8 Human SwissProt: Q9EQT3 Mouse Unigene: 647774 Human Unigene: 168257 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
WRCH1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid