GTP结合蛋白SAR1B抗体
规格：1mg/1ml
英文名： SAR1B
别名： ANDD; CMRD; GTBPB; GTP binding protein SAR1b; GTP binding protein Sara; GTP-binding protein B; GTP-binding protein SAR1B; SAR1 gene homolog B (S. cerevisiae); SAR1 homolog B; SAR1a gene homolog 2; SAR
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAR1B
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：
GTP结合蛋白SAR1B抗体产品介绍：background: The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Subunit: Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Subcellular Location: Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-GTP结合蛋白SAR1B抗体nuclear Golgi region. Tissue Specificity: Expressed in many tissues including small intestine, liver, muscle and brain. DISEASE: Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particlesGTP结合蛋白SAR1B抗体 in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Similarity: Belongs to the small GTPase superfamily. SAR1 family. Gene ID: 51128 Database links: Entrez Gene: 51128 Human Entrez Gene: 416314 Chicken Entrez Gene: 515999 Cow Entrez Gene: 66397 Mouse Entrez Gene: 494017 Pig Entrez Gene: 287276 Rat Omim: 607690 Human SwissProt: Q3T0T7 Cow SwissProt: Q9Y6B6 Human SwissProt: Q9CQC9 Mouse SwissProt: Q5PYH3 Pig SwissProt: Q5HZY2 Rat Unigene: 432984 Human Unigene: 196592 Mouse Unigene: 36748 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GTP结合蛋白SAR1B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 结合蛋白 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid