泛素特异性蛋白酶1抗体
规格：1mg/1ml
英文名： USP1
别名： Ubiquitin specific protease 1; UBP; UBP1_HUMAN; Ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; hUBP; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1.
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human USP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
泛素特异性蛋白酶1抗体产品介绍：background: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to 泛素特异性蛋白酶1抗体have a high activity. Subunit: Interacts with FANCD2 and PCNA. Interacts with WDR48. Subcellular Location: Nucleus. Post-translational modifications: Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis. Ubiquitinated; leading to its subsequent proteasomal degradation (By similarity). Similarity: Belongs to the peptidase 泛素特异性蛋白酶1抗体C19 family. Gene ID: 7398 Database links: Entrez Gene: 7398 Human Omim: 603478 Human SwissProt: O94782 Human Unigene: 35086 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. USP1蛋白是在DNA损伤修复过程中起作用的蛋白分子，可能在癌变的过程中也起到重要作用.
泛素特异性蛋白酶1抗体产品应用：WB=1:200-1000 ELISA=1:500-5000 IHC-P=1:100-1000 IHC-F=1:100-1000 IF=1:100-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid