肌动蛋白抑制因子1抗体
规格：1mg/1ml
英文名： SACM1L
别名： Phosphatidylinositide phosphatase SAC1; SAC1; SAC1 suppressor of actin mutations 1-like (yeast); SAC1_HUMAN; SACM1L; suppressor of actin 1; Suppressor of actin mutations 1-like protein.
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SACM1L
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat,
细胞定位：细胞浆
肌动蛋白抑制因子1抗体产品介绍：background: The Saccharomyces cerevisiae SAC1 gene modulates yeast actin function and alleviates the essential requirement for phosphatidylinositol transfer protein (sec14p) activity in Golgi secretory function. The SAC1 gene product (Sac1p) is an integral membrane lipid phosphatase of the endoplasmic reticulum (ER) and the Golgi complex and contains a Sac phosphatase domain (1-2). Sac1p functions in a wide range of cellular processes including inositol metabolism, actin cytoskeletal organization, endoplasmic reticulum ATP transport, phosphatidylinositol-phospha-tidylcholine transfer protein function and multiple-drug sensitivity (3). Sac1p is an important regulator of microsomal ATP transport, providing a link between inositol phospholipid signaling and ATP-dependent processes in the yeast ER (4). Defects in Sac1p relieves the requirement for Sec14p by altering phospholipid metabolism to expand the pool of diacylglycerol in the Golgi (5). Sac1p dysfunction 肌动蛋白抑制因子1抗体exerts its pleiotropic effects on yeast Golgi function, the organization of the actin cytoskeleton, and the cellular requirement for inositol, through altered metabolism of inositol glycerophospholipids (6). These effects suggest the secretory and cytoskeletal activities are coordinated to achieve proper spatial regulation of secretion in S. cerevisiae (7). Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Detected in heart, brain, lung,肌动蛋白抑制因子1抗体 liver, kidney, pancreas and testis. Similarity: Contains 1 SAC domain. Database links: Entrez Gene: 530577 Cow Entrez Gene: 484795 Dog Entrez Gene: 101787561 Guinea pig Entrez Gene: 100065601 Horse Entrez Gene: 22908 Human Entrez Gene: 83493 Mouse Entrez Gene: 116482 Rat Entrez Gene: 791142 Zebrafish Omim: 606569 Human SwissProt: A6QL88 Cow SwissProt: Q9NTJ5 Human SwissProt: Q9EP69 Mouse SwissProt: Q9ES21 Rat SwissProt: A1L244 Zebrafish Unigene: 156509 Human Unigene: 273671 Mouse Unigene: 161978 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产肌动蛋白抑制因子1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid