转录因子同源蛋白Nkx3.1抗体
规格：1mg/1ml
英文名： Nkx3.1
别名： BAPX 2; BAPX2; Homeobox protein NK-3 homolog A; Homeobox protein Nkx 3.1; Homeobox protein Nkx-3.1; Homeobox protein Nkx3.1; NK homeobox (Drosophila) family 3 A; NK homeobox family 3 A; NK homeobox, f
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nkx3.1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
转录因子同源蛋白Nkx3.1抗体产品介绍：background: This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Subunit:转录因子同源蛋白Nkx3.1抗体 Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in the prostate and, at a lower level, in the testis. Post-translational modifications: Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues. Similarity: Belongs to the NK-3 homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 转录因子同源蛋白Nkx3.1抗体4824 Database links: Entrez Gene: 4824 Human Entrez Gene: 18095 Mouse Entrez Gene: 305999 Rat Omim: 602041 Human SwissProt: Q99801 Human SwissProt: P97436 Mouse Unigene: 55999 Human Unigene: 3520 Mouse Unigene: 43468 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子同源蛋白Nkx3.1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid