NKD2蛋白抗体
规格：1mg/1ml
英文名： NKD2
别名： hNkd2; Naked 2; Naked-2; nkd2; NKD2_HUMAN; Protein naked cuticle homolog 2.
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NKD2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
NKD2蛋白抗体产品介绍：background: This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Subcellular Location: Cell membrane. Cytoplasm. Cytoplasmic vesicle. Tissue Specificity: NKD2蛋白抗体Expressed in kidney, lung, pancreas and spleen. Post-translational modifications: Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25. Similarity: Belongs to the NKD NKD2蛋白抗体family. Contains 1 EF-hand domain. Database links: Entrez Gene: 85409 Human Omim: 607852 Human SwissProt: Q969F2 Human Unigene: 240951 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NKD2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 干细胞 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid