镁转运蛋白NIPAL4抗体
规格：1mg/1ml
英文名： NIPAL4
别名： 9530066K23Rik; ICHN; Ichthyin; ICHYN; Magnesium transporter NIPA4; NIPA like 4; NIPA like domain containing 4; NIPA-like protein 4; NIPA4_HUMAN; NIPAL4; Non-imprinted in Prader-Willi/Angelman syndrome
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NIPAL4
交叉反应：Human, Mouse,
细胞定位：细胞膜
镁转运蛋白NIPAL4抗体产品介绍：background: This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010] Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Subcellular Location: Membrane. Tissue Specificity: Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain. DISEASE: Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII) [MIM:612281]. ARCII is a disorder of keratinization with 镁转运蛋白NIPAL4抗体abnormal differentiation and desquamation of the epidermis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis). Similarity: Belongs to the NIPA family. Database 镁转运蛋白NIPAL4抗体links: Entrez Gene: 348938 Human Entrez Gene: 214112 Mouse Omim: 609383 Human SwissProt: Q0D2K0 Human SwissProt: Q8BZF2 Mouse Unigene: 4285 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
镁转运蛋白NIPAL4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid