锌指蛋白ZGPAT抗体
规格：1mg/1ml
英文名： ZGPAT
别名： dJ583P15.3; FLJ14972; G patch domain-containing protein 6; GPATC6; GPATCH6; KIAA1847; MGC44880; RP4 583P15.3; ZC3H9; ZC3HDC9; ZGPAT; ZGPAT_HUMAN; Zinc finger and G patch domain-containing protein; Zin
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZGPAT
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, Cat,
细胞定位：细胞核
锌指蛋白ZGPAT抗体产品介绍：background: ZGPAT is a 531 amino acid protein that contains a G-patch domain, which is typically found within RNA-binding proteins. Proteins that contain the G-patch domain include some tumor suppressor and DNA-damage repair proteins. ZGPAT also contains one C3H1-type zinc finger, which further supports its probable role as an RNA-binding protein. The gene encoding ZGPAT is inactivated via differential methylation in a oligodendroglioma cell line, suggesting that ZGPAT may have utility as a biomarker. There are two isoforms of ZGPAT that are produced as a result of alternative splicing events. Function: Transcription repressor that specifically锌指蛋白ZGPAT抗体 binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Subcellular Location: Nucleus.锌指蛋白ZGPAT抗体 Tissue Specificity: Widely expressed. Similarity: Contains 1 C3H1-type zinc finger. Contains 1 G-patch domain. Database links: Entrez Gene: 84619 Human Entrez Gene: 296478 Rat SwissProt: Q8N5A5 Human SwissProt: Q5PPF5 Rat Unigene: 590868 Human Unigene: 8219 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白ZGPAT抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid