锌指蛋白结构域ZFYVE28抗体
规格：1mg/1ml
英文名： ZFYVE28
别名： hLst2; Lateral signaling target protein 2 homolog; LST2; LST2_HUMAN; LYST2; MGC43699; MGC61592; zfyve28; Zinc finger FYVE domain containing 28; Zinc finger FYVE domain-containing protein 28.
分子量： 96kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZFYVE28
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
锌指蛋白结构域ZFYVE28抗体产品介绍：background: ZFYVE28 is an 887 amino acid protein that contains one FYVE-type zinc finger, which mediates the interaction with PI3P (phosphatidylinositol 3-phosphate). ZFYVE28 functions as a negative regulator of EGFR (epidermal growth factor receptor) by promoting its degradation in endosomes when not monoubiquinated on Lys-87. In the absence of monoubiquination, ZFYVE28 localizes to the early endosome membrane, while it localizes to the cytosol when it is monoubiquinated. There are five isoforms of ZFYVE28 that are produced as a result of alternative splicing events. Function: Negative regulator of epidermal growth factor receptor 锌指蛋白结构域ZFYVE28抗体(EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. Subcellular Location: Cytoplasm > cytosol. Early endosome membrane. Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated. Post-translational modifications: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Similarity: Belongs to the lst-2 family. Contains 1 FYVE-type zinc finger. Gene ID: 57732锌指蛋白结构域ZFYVE28抗体 Database links: Entrez Gene: 57732 Human Entrez Gene: 231125 Mouse Omim: 614176 Human SwissProt: Q9HCC9 Human SwissProt: Q6ZPK7 Mouse Unigene: 292056 Human Unigene: 113388 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白结构域ZFYVE28抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid