肌球蛋白调节轻链12B抗体
规格：1mg/1ml
英文名： MYL12B
别名： ML12B_HUMAN; MLC-2; MLC-2a; MLC-B; MLC20; MRLC2; MYL12B; MYLC2B; Myosin light chain 12B regulatory; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2-
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYL12B
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
肌球蛋白调节轻链12B抗体产品介绍：background: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008] Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Tissue Specificity: Ubiquitously expressed in various hematopoietic cells. Post-translational modifications: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the 肌球蛋白调节轻链12B抗体contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. Similarity: Contains 肌球蛋白调节轻链12B抗体3 EF-hand domains. Gene ID: 103910 Database links: Entrez Gene: 103910 Human Entrez Gene: 67938 Mouse Entrez Gene: 50685 Rat Omim: 609211 Human SwissProt: O14950 Human SwissProt: Q3THE2 Mouse SwissProt: P18666 Rat Unigene: 190086 Human Unigene: 464472 Human Unigene: 261329 Mouse Unigene: 485011 Mouse Unigene: 214633 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌球蛋白调节轻链12B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid