黑色素瘤抑制活性蛋白3抗体
规格：1mg/1ml
英文名： MIA3
别名： ARNT; C219 reactive peptide; C219-reactive peptide; D320; Melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; Mia3; MIA3_HUMAN; RP11-378J18.4; TANGO; TANGO1; Transpo
分子量： 214kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIA3
交叉反应：Human, Mouse, Rat,
细胞定位：
黑色素瘤抑制活性蛋白3抗体产品介绍：Function: Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. Subcellular Location: Endoplasmic 黑色素瘤抑制活性蛋白3抗体reticulum membrane. Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. Tissue Specificity: Broadly expressed, 黑色素瘤抑制活性蛋白3抗体except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. Similarity: Belongs to the MIA/OTOR family. Tango1 subfamily. Contains 1 SH3 domain. Gene ID: 375056 Database links: Entrez Gene: 375056 Human Omim: 613455 Human SwissProt: Q5JRA6 Human Unigene: 118474 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
黑色素瘤抑制活性蛋白3抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid