SEL1L抗体
规格：1mg/1ml
英文名： SEL1L
别名： IBD2; PRO1063; Protein sel-1 homolog 1; SE1L1_HUMAN; Sel 1 like protein; Sel 1 suppressor of lin 12 like; Sel-1L; SEL1 LIKE; Sel1l; SEL1LIKE; Suppressor of lin-12-like protein 1; TSA305; UNQ128; UNQ12
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SEL1L
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：
SEL1L抗体产品介绍：background: SEL1L, highly similar to the C elegans sel-1 gene, is a recently cloned human gene whose function is under investigation. SEL1L is differentially expressed in tumors and normal tissues and seems to play a role in tumor growth and aggressiveness. It may be an important negative regulator of the "notch" pathway which acts as a key regulator of the cellular proliferation and specification processes in both vertebrates and invertebrates. SEL1L may function in the protein degradation processes through the ubiquitin-proteosome system and perhaps in regulating important pathways such TGF-beta. It is ubiquitously expressed only in fetal and neoplastic tissues. In normal ***** tissues is highly expressed in the acini and in the alpha cells of the pancreas; in general it is highly represented in secretory cells such as plasma cells. Function: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system alsoSEL1L抗体 called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Subunit: Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in pancreas. Post-translational modifications: N-glycosylated. Similarity: Belongs to the sel-1 family. Contains 1 fibronectin type-II domain.SEL1L抗体 Contains 11 Sel1-like repeats. Gene ID: 6400 Database links: Entrez Gene: 6400 Human Entrez Gene: 20338 Mouse Entrez Gene: 116488 Rat Entrez Gene: 314352 Rat Omim: 602329 Human SwissProt: Q12916 Human SwissProt: Q9UBV2 Human SwissProt: Q9Z2G6 Mouse SwissProt: Q80Z70 Rat Unigene: 181300 Human Unigene: 250605 Mouse Unigene: 162892 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SEL1L抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid