SCN2A抗体
规格：1mg/1ml
英文名： SCN2A
别名： sodium channel voltage-gated type II alpha; sodium channel, voltage-gated, type II, alpha isoform 2; HBSC II; NAC2; Scn2a; SCN2A_HUMAN; Sodium channel protein type II subunit alpha; Sodium channel pro
分子量： 228kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCN2A
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
SCN2A抗体产品介绍：background: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Subunit: The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Post-translational modifications: SCN2A抗体May be ubiquitinated by NEDD4L; which would promote its endocytosis (By similarity). DISEASE: Defects in SCN2A are the cause of benign familial infantile convulsions type 3 (BFIC3) [MIM:607745]. BFIC3 is an autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11) SCN2A抗体[MIM:613721]. EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. Contains 1 IQ domain. Gene ID: 6326 Database links: Entrez Gene: 6326 Human Entrez Gene: 110876 Mouse Entrez Gene: 24766 Rat Omim: 182390 Human SwissProt: Q99250 Human SwissProt: P04775 Rat Unigene: 93485 Human Unigene: 220329 Mouse Unigene: 89192 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SCN2A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid