染色质解旋酶DNA结合蛋白3抗体
规格：1mg/1ml
英文名： CHD3
别名： 226; 2600010P09Rik; AF020312; ATP dependent helicase CHD3; ATP-dependent helicase Chd3; CHD-3; Chd3; CHD3_HUMAN; Chd7; Chromodomain-helicase-DNA-binding protein 3; hZFH; MGC40857; Mi 2 autoantigen 240
分子量： 226kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHD3
交叉反应：Human, Mouse, Rat, Dog, Cow, Chimpanzee,
细胞定位：细胞核 细胞浆
染色质解旋酶DNA结合蛋白3抗体产品介绍：background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessiblity to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Chromatin structure alteration may be brought about by the action of ATP-dependent multiprotein complexes. One such complex is the mSin3 corepressor complex, which contains mSin3, the histone deacetylases HDAC1 and HDAC2, the associated proteins SAP 30 and SAP 18, and the autoantigens Mi2-a and Mi2-b. Function: Component of the histone deacetylase NuRD complex which染色质解旋酶DNA结合蛋白3抗体 participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Subcellular Location: Nucleus. Cytoplasm > cytoskeleton > centrosome. Associates with centrosomes in interphase and mitosis. Tissue Specificity: Widely expressed. Similarity: Belongs to the SNF2/RAD54 染色质解旋酶DNA结合蛋白3抗体helicase family. Contains 2 chromo domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 PHD-type zinc fingers. Database links: Entrez Gene: 455278 Chimpanzee Entrez Gene: 1107 Human Entrez Gene: 216848 Mouse Entrez Gene: 303241 Rat Omim: 602120 Human SwissProt: Q12873 Human Unigene: 25601 Human Unigene: 178246 Mouse Unigene: 234402 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色质解旋酶DNA结合蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid