染色质解旋酶DNA结合蛋白抗体
规格：1mg/1ml
英文名： CHD1L
别名： ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; chd1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FL
分子量： 101kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHD1L
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞核
染色质解旋酶DNA结合蛋白抗体产品介绍：background: CHD1L is a 897 amino acid protein encoded by the human gene CHD1L. The CHD family of proteins are ATP-dependent chromatin remodeling enzymes, which combine chromodomains, with SWI2/SNF2 ATPase/helicase motifs and DNA-binding capability. Chromodomains are protein regions of about 40-50 amino acid residues found in proteins associated with chromatin remodeling and manipulation. The domain is highly conserved among both plants and animals and is found in a large variety of proteins from many genomes. CHD1L and CHD1 share most homology within two internal helicase domains. Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions 染色质解旋酶DNA结合蛋白抗体to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Subunit: Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated). Subcellular Location: Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. 染色质解旋酶DNA结合蛋白抗体Tissue Specificity: Frequently overexpressed in hepatomacellular carcinomas. Similarity: Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 Macro domain. Database links: Entrez Gene: 9557 Human Entrez Gene: 68058 Mouse Omim: 613039 Human SwissProt: Q86WJ1 Human SwissProt: Q9CXF7 Mouse Unigene: 191164 Human Unigene: 41447 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色质解旋酶DNA结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid