促代谢型谷氨酸受体7抗体
规格：1mg/1ml
英文名： mGluR7
别名： FLJ40498; GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87; GLUR7; Glutamate receptor metabotropic 7; GPRC1G; GRM7; GRM7_HUMAN; Metabotropic glutamate receptor 7; mGluR7; OTTHUMP00000206961; OTTHUMP00000214674;
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human mGluR7
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
促代谢型谷氨酸受体7抗体产品介绍：background: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Subunit: 促代谢型谷氨酸受体7抗体Interacts with PICK1. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. Similarity: Belongs to the G-protein coupled receptor 3 family. Gene ID: 2917 Database links: Entrez Gene: 535362 促代谢型谷氨酸受体7抗体Cow Entrez Gene: 484674 Dog Entrez Gene: 2917 Human Entrez Gene: 108073 Mouse Entrez Gene: 81672 Rat Entrez Gene: 564461 Zebrafish Omim: 604101 Human SwissProt: Q14831 Human SwissProt: Q68ED2 Mouse SwissProt: P35400 Rat Unigene: 606393 Human Unigene: 660131 Human Unigene: 240881 Mouse Unigene: 10409 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
促代谢型谷氨酸受体7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid