细胞周期调控因子P78抗体
规格：1mg/1ml
英文名： MCRS1/p78
别名： 58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUM
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MCRS1/p7
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核
细胞周期调控因子P78抗体产品介绍：background: MSP58 is a 462 amino acid protein that localizes to the nucleus and contains one FHA domain. Expressed at high levels during the S phase of the cell cycle and present in testis, prostate, thymus, spleen and colon, MSP58 functions to modulate the transcriptional activity of Daxx (a transcriptional repressor) by recruiting Daxx to the nucleolus. Additionally, MSP58 may play a role in the inhibition of TERT telomerase activity, further implicating MSP58 as an important protein in transcriptional regulation. The gene encoding MSP58 maps to human chromosome 12 and is expressed as multiple alternatively spliced isoforms. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome and is associated wirh hypochondrogenesis, achondrogenesis and Kniest dysplasia. Function: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. May be an inhibitor of 细胞周期调控因子P78抗体TERT telomerase activity. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Subcellular Location: Nucleus. Nucleus > nucleolus. In microspherules in the nucleolus. Tissue Specificity: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes. Similarity细胞周期调控因子P78抗体: Contains 1 FHA domain. Gene ID: 10445 Database links: Entrez Gene: 10445 Human Entrez Gene: 51812 Mouse Entrez Gene: 300222 Rat Omim: 609504 Human SwissProt: Q96EZ8 Human SwissProt: Q99L90 Mouse Unigene: 25313 Human Unigene: 383472 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞周期调控因子P78抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid