程序性死亡1抗体
规格：1mg/1ml
英文名： PD-1
别名： programmed death 1; CD279; CD 279; CD279 antigen; hPD 1; PD 1; PD-1; PD1; PDCD 1; PDCD1; Programmed cell death 1; Programmed Cell Death Protein 1; Protein PD 1; SLEB2.
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PD-1
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞膜
程序性死亡1抗体产品介绍：background: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. CD279 is an immunoglobulin superfamily member, also known as Programmed Cell Death 1. Programmed Cell Death 1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B程序性死亡1抗体 cells. Programmed Cell Death 1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The Programmed Cell Death 1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily. Subunit: Monomer (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Ta,Ba,Ma,Thy Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 5133 Database links: Entrez Gene: 5133 Human Entrez Gene: 18566 Mouse Entrez Gene: 301626 Rat Omim: 600244程序性死亡1抗体 Human SwissProt: Q15116 Human SwissProt: Q02242 Mouse Unigene: 158297 Human Unigene: 5024 Mouse Unigene: 105023 Rat Important Note: This product as supplied is intended for 程序性死亡1抗体research use only, not for use in human, therapeutic or diagnostic applications. 配体为B7H1/PDL1(CD274)和B7DC/PDL2，抑制活化T细胞的增殖和细胞因子的产生，抑制B细胞功能，参与**耐受
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid