干扰素诱导蛋白p58ipk抗体
规格：1mg/1ml
英文名： DNAJC3
别名： DNAJC3; p58ipk; Protein Kinase Inhibitor P58; DnaJ homolog subfamily C member 3; HP58; Interferon induced, double stranded RNA activated protein kinase inhibitor; P58; p58 ipk ; P58IPK; PRKRI; Protein
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human p58ipk
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
干扰素诱导蛋白p58ipk抗体产品介绍：background: DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable). Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation 干扰素诱导蛋白p58ipk抗体of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Subcellular Location: Endoplasmic reticulum. Tissue Specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Similarity: Contains 1 J domain. Contains 9 TPR repeats. Gene ID: 5611 Database links: Entrez Gene: 5611干扰素诱导蛋白p58ipk抗体 Human Entrez Gene: 100037258 Mouse Entrez Gene: 63880 Rat Omim: 601184 Human SwissProt: Q13217 Human SwissProt: Q91YW3 Mouse SwissProt: Q9R0T3 Rat Unigene: 59214 Human Unigene: 12616 Mouse Unigene: 162234 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素诱导蛋白p58ipk抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid