基质金属蛋白酶-17抗体
规格：1mg/1ml
英文名： MMP17
别名： Matrix metalloproteinase-17; MMP-17; MMP 17; MMP17; MTMMP 4; Matrix metalloproteinase 17; Matrix metalloproteinase 17 membrane inserted; Membrane type 4 matrix metalloproteinase; Membrane type matrix
分子量： 48/63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMP17
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
基质金属蛋白酶-17抗体产品介绍：background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008] Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin基质金属蛋白酶-17抗体. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. Subcellular Location: Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed in brain, leukocytes, colon,基质金属蛋白酶-17抗体 ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types. Post-translational modifications: The precursor is cleaved by a furin endopeptidase. Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Gene ID: 4326 Database links: Entrez Gene: 4326 Human Entrez Gene: 23948 Mouse Entrez Gene: 288626 Rat Omim: 602285 Human SwissProt: Q9ULZ9 Human SwissProt: Q9R0S3 Mouse Unigene: 709245 Human Unigene: 42047 Mouse Unigene: 7971 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
基质金属蛋白酶-17抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid