膜相关鸟苷酸激酶3抗体
规格：1mg/1ml
英文名： MAGI3
别名： dJ730K3.2; MAGI-3; magi3; MAGI3_HUMAN; Membrane Associated Guanylate kinase Related 3; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; RP4-730K3.1; SLIPR; WW and
分子量： 123kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAGI3
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
膜相关鸟苷酸激酶3抗体产品介绍：background: MAGE-H1 is a 219 amino acid protein that contains a type II MAGE homology domain (MHD). Enhanced ligand stimulation promotes MAGE-H1 interaction with the type II death domain of NGFR p75. It is suggested that MAGE-H1 accelerates differentiation in response to nerve growth factor in cells. Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Subcellular Location: Cell membrane. Cell junction > tight junction. 膜相关鸟苷酸激酶3抗体Nucleus. Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions. Tissue Specificity: Widely expressed. Post-translational modifications: Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Similarity: Belongs to the MAGUK family. Contains 1膜相关鸟苷酸激酶3抗体 guanylate kinase-like domain. Contains 6 PDZ (DHR) domains. Contains 2 WW domains. Database links: Entrez Gene: 260425 Human Entrez Gene: 99470 Mouse Entrez Gene: 245903 Rat SwissProt: Q5TCQ9 Human SwissProt: Q9EQJ9 Mouse SwissProt: Q9JK71 Rat Unigene: 486189 Human Unigene: 264849 Mouse Unigene: 162623 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜相关鸟苷酸激酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 激酶和磷酸酶 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid