癌/睾丸抗原128抗体
规格：1mg/1ml
英文名： MAEL/CT128
别名： cancer/testis antigen 128; CT128; FLJ14904; mael; MAEL_HUMAN; maelstrom homolog (Drosophila); Maelstrom homolog; OTTHUMP00000032344; Protein maelstrom homolog; RP11-102C16.1.
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAEL/CT1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
癌/睾丸抗原128抗体产品介绍：background: Mael is a 434 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one HMG box DNA-binding domain. Expressed specifically in testicular tissue, Mael interacts with Ini1, mSin3B and VASA and plays an essential role in spermatogenesis, specifically by repressing and, ultimately, preventing the mobilization of transposable elements (a process that is crucial for germline integrity). Multiple isoforms of Mael exist due to alternative splicing events. The gene encoding Mael maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, 癌/睾丸抗原128抗体including head and neck cancer, malignant melanoma and multiple myeloma. Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage. Subcellular Location: Cytoplasm. Nucleus. Component of the meiotic 癌/睾丸抗原128抗体nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. Tissue Specificity: Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. Similarity: Belongs to the maelstrom family. Contains 1 HMG box DNA-binding domain. Gene ID: 84944 Database links: Entrez Gene: 84944 Human Entrez Gene: 98558 Mouse Entrez Gene: 364039 Rat Omim: 611368 Human SwissProt: Q96JY0 Human SwissProt: Q8BVN9 Mouse Unigene: 651245 Human Unigene: 26189 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
癌/睾丸抗原128抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid