**细胞抗原Ly6D抗体
规格：1mg/1ml
英文名： LY6D
别名： E48 antigen; LY 6D; LY-6D;Lymphocyte antigen 6 complex; LY6D_HUMAN; Lymphocyte antigen 6 complex locus D; Lymphocyte antigen D; Lymphocyte antigen 6D.
分子量： 8.4kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LY6D
交叉反应：Human,
细胞定位：细胞膜
**细胞抗原Ly6D抗体产品介绍：background: Ly-6D is a 128 amino acid glycoprotein that is expressed in squamous cell carcinoma cell lines and squamous cell epithelia tissue. Ly-6D contains a signal peptide, 2 theoretical phosphorylation sites and 3 putative myristoylation sites. Upregulation of the gene encoding Ly-6D in head and neck cancers is associated with poor prognosis and high expression of Ly-6D has been linked to enhanced cell migration. Ly-6D is frequently used as a molecular marker for diagnosis and therapy of head-and-neck squamous cell carcinoma (HNSCC). It has been suggested that Ly-6D may regulate the expression levels of certain fucosylated E-selectin ligands and protein FX, **细胞抗原Ly6D抗体a protein that contributes to the last step in the synthesis of GDP-L-fucose, in HNSCC cell lines. This finding is indicative that Ly-6D may regulate tumor cell adhesion in inflamed vessel walls that express E-selectin. Function: May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. Subcellular Location: Cell membrane**细胞抗原Ly6D抗体; Lipid-anchor ?GPI-anchor Tissue Specificity: Expressed exclusively at the outer cell surface of transitional epithelia and the keratinocyte of stratified squamous epithelia. Similarity: Contains 1 UPAR/Ly6 domain. Database links: http://www.ncbi.nlm.nih.gov/protein/2501524 UniProtKB/Swiss-Prot: Q14210.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
**细胞抗原Ly6D抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 **细胞 t-**细胞 b-**细胞
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid