亮氨酸拉链抑癌蛋白2抗体
规格：1mg/1ml
英文名： LZTS2
别名： hLZTS2; KIAA1813; LAPSER1; Leucine zipper putative tumor suppressor 2; LZTS2; LZTS2_HUMAN; OTTHUMP00000020289; Protein LAPSER1; RP11-108L7.8.
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LZTS2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat,
细胞定位：细胞浆
亮氨酸拉链抑癌蛋白2抗体产品介绍：background: LAPSER1 is a member of the LZTS family. Due to its deletion in multiple cancers, including prostate tumors, LAPSER1 is purported to be a tumor suppressor. In cancer cell lines, the overexpression of LAPSER1 can lead to growth inhibition and colony-forming efficiency. LAPSER1 is highly expressed in testis and prostate, but can be detected at lower levels in spleen, thymus, uterus, small intestine and colon. LAPSER1 colocalizes with ?tubulin, MKLP-1 and p80 katanin. LAPSER1 is involved in cytokinesis. The disruption of LAPSER1, which is accompanied by the mislocalization of p80 katanin, results in malformation of the central spindle. This is a potential impetus for carcinogenesis. Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle亮氨酸拉链抑癌蛋白2抗体 formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. Tissue Specificity: Highly expressed in亮氨酸拉链抑癌蛋白2抗体 prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. Similarity: Belongs to the LZTS2 family. Gene ID: 84445 Database links: Entrez Gene: 504411 Cow Entrez Gene: 84445 Human Entrez Gene: 226154 Mouse Entrez Gene: 365468 Rat Omim: 610454 Human SwissProt: A5PKL7 Cow SwissProt: Q9BRK4 Human SwissProt: Q91YU6 Mouse SwissProt: Q3LUD4 Rat Unigene: 523221 Human Unigene: 28204 Mouse Unigene: 23951 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亮氨酸拉链抑癌蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid