ZSWIM7蛋白抗体
规格：1mg/1ml
英文名： ZSWIM7
别名： SWIM domain-containing and Srs2-interacting protein 1 homolog; SWIM domain-containing Srs2-interacting protein 1; SWIM-type zinc finger domain-containing protein 7; SWS1; Zinc finger SWIM domain-conta
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZSWIM7
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
ZSWIM7蛋白抗体产品介绍：background: ZSWIM7 is a 140 amino acid nuclear protein that contains a SWIM-type zinc finger and belongs to the SWS1 family. ZSWIM7 interacts with Rad51D, and plays a role in the early stages of the homologous recombination repair (HRR) pathway that occurs during double-stranded DNA breaks. The gene encoding ZSWIM7 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 ZSWIM7蛋白抗体is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Involved in early stages of the homologousZSWIM7蛋白抗体 recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Subcellular Location: Nucleus. Similarity: Belongs to the SWS1 family. Contains 1 SWIM-type zinc finger. Database links: Entrez Gene: 125150 Human Omim: 614535 Human SwissProt: Q19AV6 Human Unigene: 593985 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ZSWIM7蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid