基质金属蛋白酶-12抗体
规格：1mg/1ml
英文名： MMP12
别名： matrix metalloproteinase 12; MMP12; EC 3.4.24.65; HME; Macrophage elastase; Macrophage metaloelastase; Matrix metalloprotease 12; ME; MGC138506; MME; MMP 12; MMP12_HUMAN; MMP 12; MMP-12; MMP12.
分子量： 40/49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMP12
交叉反应：Human, Mouse, Rat,
细胞定位：细胞外基质 分泌型蛋白
基质金属蛋白酶-12抗体产品介绍：background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 was first described in murine macrophages, later in human macrophages, and more recently in other cell types. Also known as metalloelastase, MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and基质金属蛋白酶-12抗体 hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Tissue Specificity: Found in alveolar macrophages but not in peripheral blood monocytes. Similarity: 基质金属蛋白酶-12抗体Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Gene ID: 4321 Database links: Entrez Gene: 4321 Human Entrez Gene: 17381 Mouse Entrez Gene: 117033 Rat Omim: 601046 Human SwissProt: P39900 Human SwissProt: P34960 Mouse SwissProt: Q63341 Rat Unigene: 1695 Human Unigene: 2055 Mouse Unigene: 33193 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MMP12(巨噬细胞金属弹力蛋白酶)可使纤溶酶原转化为血管稳定因子(angiostatin),是一种重要的肿瘤血管形成的抑制因子。
基质金属蛋白酶-12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid