细胞生长调节核仁蛋白抗体
规格：1mg/1ml
英文名： LYAR
别名： Cell growth regulating nucleolar protein; Cell growth-regulating nucleolar protein; Likely ortholog of mouse Ly1; reactive clone; Ly1; reactive; Ly1; reactive homolog (mouse); Ly1; reactive homolog; L
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LYAR
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
产细胞生长调节核仁蛋白抗体品介绍：background: LYAR is a 379 amino acid nucleolar protein containing two C2HC-type zinc fingers. Expressed at high levels in immature spermatocytes, early embryos and in fetal liver and thymus with low expression in kidney and spleen, LYAR may function as a novel nucleolar oncoprotein to regulate cell growth. It is suggested that LYAR participates in regulating the stability of C23, a protein that is critical for maintaining the self-renewal and differentiation of embryonic stem cells (ESCs). C23 is a eukaryotic nucleolar 细胞生长调节核仁蛋白抗体phosphoprotein that influences synthesis and maturation of ribosomes. LYAR forms a complex with C23, thereby preventing self-cleavage and maintaining steady levels of C23 in undifferentiated ESCs. Downregulation of LYAR decreases C23 stability in ESCs,细胞生长调节核仁蛋白抗体 which in turn negatively affects growth and increases the rate of apoptosis of these cells. Subcellular Location: Nucleus Similarity: Contains 2 C2HC-type zinc fingers. Gene ID: 55646 Database links: Entrez Gene: 55646 Human Entrez Gene: 17089 Mouse Entrez Gene: 289707 Rat SwissProt: Q9NX58 Human SwissProt: Q08288 Mouse SwissProt: Q6AYK5 Rat细胞生长调节核仁蛋白抗体 Unigene: 425427 Human Unigene: 28560 Mouse Unigene: 137862 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid