LSM10相关蛋白抗体
规格：1mg/1ml
英文名： LSM10
别名： LSM 10; LSM10 U7 small nuclear RNA associated; MGC15749; MST074; LSM10_HUMAN; MSTP074; U7 snRNA associated Sm like protein LSm10; U7 snRNP specific Sm like protein LSM10.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LSM10
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞核
LSM10相关蛋白抗体产品介绍：background: LSM10 is a 14 kDa polypeptide that is a member of the Sm/Lsm protein family. Like U7 snRNA, LSM10 is enriched in Cajal or coiled bodies (CBs) in the nucleus. LSM10 associates with the U7 snRNP and this interaction is dictated by the special Sm binding site of U7 snRNA. Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, LSM10相关蛋白抗体SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN. Subcellular Location: Nuclear Post-translational modifications: Not methylated. Methylation is not necessary for interactionLSM10相关蛋白抗体 with SMN. Similarity: Belongs to the snRNP Sm proteins family. Gene ID: 84967 Database links: Entrez Gene: 84967 Human Entrez Gene: 116748 Mouse Entrez Gene: 366468 Rat SwissProt: Q969L4 Human SwissProt: Q8QZX5 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LSM10相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid