卵磷脂视黄醇酰基转移酶抗体
规格：1mg/1ml
英文名： LRAT
别名： LCA14; Lecithin retinol acyltransferase (phosphatidylcholine retinol O acyltransferase); Lecithin retinol acyltransferase; LRAT; LRAT_HUMAN; Phosphatidylcholine retinol O acyltransferase; Phosphatidyl
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRAT
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞浆
卵磷脂视黄醇?；泼缚固?/strong>产品介绍：background: The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq, Jul 2008] Function: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Subcellular Location: Endoplasmic reticulum membrane. Rough endoplasmic reticulum. Endosome > multivesicular body. Cytoplasm > perinuclear region. Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells. Tissue Specificity: Hepatic stellate 卵磷脂视黄醇?；泼缚固?/strong>cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. DISEASE: Defects in LRAT are a cause of Leber congenital amaurosis type 14 (LCA14) [MIM:613341]. It is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or 卵磷脂视黄醇?；泼缚固?/strong>near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Similarity: Belongs to the H-rev107 family. Gene ID: 9227 Database links: Entrez Gene: 9227 Human Entrez Gene: 79235 Mouse Entrez Gene: 64047 Rat Omim: 604863 Human SwissProt: O95237 Human SwissProt: Q9JI60 Mouse SwissProt: Q9JI61 Rat Unigene: 658427 Human Unigene: 33921 Mouse Unigene: 137431 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
卵磷脂视黄醇酰基转移酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid