肝羧酸酯酶1抗体
规格：1mg/1ml
英文名： CES1/Liver Carboxylesterase 1
别名： ACAT; Acyl coenzyme A cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxyesterase ES-3; Carboxylesterase; Carboxylesterase 1 (monocyte/macrop
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CES1/Liv
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞浆
肝羧酸酯酶1抗体产品介绍：background: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no 肝羧酸酯酶1抗体catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Subcellular Location: Endoplasmic reticulum lumen. Tissue Specificity: Expressed predominantly in liver with lower levels in heart and lung. Post-translational modifications: Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or肝羧酸酯酶1抗体 between Gly-18 and His-19. Similarity: Belongs to the type-B carboxylesterase/lipase family. Gene ID: 1066 Database links: Entrez Gene: 1066 Human Entrez Gene: 12623 Mouse Entrez Gene: 24346 Rat Entrez Gene: 29225 Rat Omim: 114835 Human SwissProt: P23141 Human SwissProt: Q8VCC2 Mouse SwissProt: P10959 Rat SwissProt: Q63108 Rat Unigene: 558865 Human Unigene: 22720 Mouse Unigene: 2549 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝羧酸酯酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid