LIM同源框蛋白1抗体
规格：1mg/1ml
英文名： LIM1
别名： hLim-1; Homeo box protein Lim 1; Homeo box protein Lim1; Homeobox protein Lim 1; Homeobox protein Lim-1; Homeobox protein Lim1; LHX 1; LHX1; LHX1_HUMAN; LIM 1; LIM homeo box 1; LIM homeo box protein 1
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LIM1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Chimpanzee,
细胞定位：细胞核
LIM同源框蛋白1抗体产品介绍：background: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Potential transcription factor. May play a role in early LIM同源框蛋白1抗体mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. Subcellular Location: Nucleus. Tissue Specificity: Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. Gene ID: 3975LIM同源框蛋白1抗体 Database links: Entrez Gene: 454600 Chimpanzee Entrez Gene: 3975 Human Entrez Gene: 16869 Mouse Entrez Gene: 257634 Rat Omim: 601999 Human SwissProt: Q5IS44 Chimpanzee SwissProt: P48742 Human SwissProt: P63006 Mouse SwissProt: P63007 Rat Unigene: 443727 Human Unigene: 4965 Mouse Unigene: 127825 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LIM同源框蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 染色质和核信号 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid