心脏肌球蛋白轻链2抗体
规格：1mg/1ml
英文名： MYL2
别名： Cardiac myosin light chain-2; Cardiac ventricular myosin light chain 2; CMH10; MLC 2v; MLC-2; MLC-2v; MLC2; MLRV_HUMAN; MYL 2; MYL2; Myosin light chain 2 regulatory cardiac slow; Myosin light polypept
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cardiac
交叉反应：Human, Mouse, Rat, Chicken, Pig, Rabbit,
细胞定位：细胞浆
心脏肌球蛋白轻链2抗体产品介绍：background: Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains. Tissue Specificity: Expressed in fetal and ***** skeletal muscle. Post-translational modifications: N-terminus is methylated by METTL11A/NTM1. DISEASE: Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. 心脏肌球蛋白轻链2抗体The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]心脏肌球蛋白轻链2抗体. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. Similarity: Contains 3 EF-hand domains. Gene ID: 4633 Database links: Entrez Gene: 505519 Cow Entrez Gene: 403614 Dog Entrez Gene: 4633 Human Entrez Gene: 17906 Mouse Entrez Gene: 363925 Rat Omim: 160781 Human SwissProt: Q3SZE5 Cow SwissProt: P10916 Human SwissProt: P51667 Mouse SwissProt: P08733 Rat Unigene: 48942 Cow Unigene: 75535 Human Unigene: 1529 Mouse Unigene: 37176 Rat Unigene: 6534 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
心脏肌球蛋白轻链2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid