早期生长应答蛋白1靶向蛋白1抗体
规格：1mg/1ml
英文名： TOE1
别名： Target of EGR1 protein 1; target of EGR1, member 1; Toe1; TOE1_HUMAN.
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TOE1
交叉反应：Human,
细胞定位：细胞核
早期生长应答蛋白1靶向蛋白1抗体产品介绍：background: TOE1 is a 510 amino acid long protein that belongs to the CAF1 family. It is a downstream target of EGR-1 and plays an important role mediating the inhibitory growth effect of EGR-1. EGR-1 directly binds the TOE1 promoter region and activates its expression. TOE1 induces the expression of TGF∫ and p21 and plays a role in cell cycle regulation and the inhibition of cell growth. The activity and nucleolar localization of TOE1 correlates with a G2 cell cycle phase delay which is likely due to an increased expression of p21. In addition, TOE1 may function via an interaction with p53 and possible modification to its activity. TOE1 is expressed at various levels in all ***** tissues and specifically localizes to the nuclear speckles. Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression a早期生长应答蛋白1靶向蛋白1抗体s well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Subcellular Location: Nucleus > nucleolus. Nucleus speckle. Localizes to nuclear speckles. Similarity: Belongs to the CAF1 family. Contains 1 C3H1-type zinc finger. Gene ID: 114034 Database links: Entrez Gene: 114034 Human Entrez Gene: 68276 Mouse Entrez Gene: 298443 Rat Omim: 613931 Human SwissProt: Q96GM8 早期生长应答蛋白1靶向蛋白1抗体Human SwissProt: Q9D2E2 Mouse Unigene: 525091 Human Unigene: 30534 Mouse Unigene: 105772 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
早期生长应答蛋白1靶向蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid