张力蛋白4抗体
规格：1mg/1ml
英文名： TNS4
别名： C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4.
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNS4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
张力蛋白4抗体产品介绍：background: The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a 张力蛋白4抗体role in tumor suppression Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3. Subcellular Location: Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Tissue Specificity: Prostate and placenta. Down regulated in prostate cancer. Post-translational modifications: Proteolytically cleaved by caspase-3 during apoptosis. Similarity: Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain. Gene ID: 84951 Database links: Entrez 张力蛋白4抗体Gene: 84951 Human Entrez Gene: 217169 Mouse Omim: 608385 Human SwissProt: Q8IZW8 Human SwissProt: Q8BZ33 Mouse Unigene: 438292 Human Unigene: 262067 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
张力蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid