蛋氨酸亚砜还原酶B3抗体
规格：1mg/1ml
英文名： MSRB3
别名： Deafness, Autosomal Recessive 74; DFNB74; FLJ36866; Methionine R sulfoxide reductase B mitochondrial; Methionine sulfoxide reductase B3; Methionine-R-sulfoxide reductase B3; MsrB3; Msrb3; MSRB3_HUMAN.
分子量： 173kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MSRB3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
蛋氨酸亚砜还原酶B3抗体产品介绍：background: The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010] Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. Subcellular Location: Mitochondrion and Endoplasmic reticulum. Tissue Specificity: Widely expressed. DISEASE: Deafness, autosomal recessive,蛋氨酸亚砜还原酶B3抗体 74 (DFNB74) [MIM:613718]: A form of non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry. A nonsense 蛋氨酸亚砜还原酶B3抗体mutation affecting exclusively mitochondrial isoform 2 is sufficient to produce hearing loss. Similarity: Belongs to the MsrB Met sulfoxide reductase family. Gene ID: 253827 Database links: Entrez Gene: 253827 Human Entrez Gene: 320183 Mouse Entrez Gene: 680036 Rat Omim: 613719 Human SwissProt: Q8IXL7 Human SwissProt: Q8BU85 Mouse Unigene: 339024 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产蛋氨酸亚砜还原酶B3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 新陈代谢 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid