6号染色体开放阅读框抗体
规格：1mg/1ml
英文名： MMS22L/C6orf167
别名： C6orf167; C6orf167 chromosome 6 open reading frame 167; chromosome 6 open reading frame 167; dJ39B17.2; DKFZp686C20164; DKFZp781C2113; FLJ46180; homologous to yeast Mms22; KIAA1900; Methyl methanesulf
分子量： 142kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMS22L/C
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
6号染色体开放阅读框抗体产品介绍：background: Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple6号染色体开放阅读框抗体 syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf167 gene product has been provisionally designated C6orf167 pending further characterization. Function: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated 6号染色体开放阅读框抗体repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Subcellular Location: Nucleus. Localizes to DNA damage sites, accumulates at stressed replication forks. Similarity: Belongs to the MMS22 family. MMS22L subfamily. Gene ID: 253714 Database links: Entrez Gene: 253714 Human Entrez Gene: 212377 Mouse SwissProt: Q6ZRQ5 Human SwissProt: B1AUR6 Mouse Unigene: 444292 Human Unigene: 120919 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
6号染色体开放阅读框抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 糖尿病 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid