内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4抗体
规格：1mg/1ml
英文名： Ephrin A1
别名： B61; ECKLG; EFL 1; EFL1; EFNA 1; EFNA1; EFNA1_HUMAN; EPH related receptor tyrosine kinase ligand 1; EPH-related receptor tyrosine kinase ligand 1; Ephrin-A1; Ephrin-A1, secreted form; EphrinA1; EPLG 1
分子量： 19/22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Ephrin A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4抗体产品介绍：background: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008] Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4抗体 contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Subunit: Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, 内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4抗体EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Ephrin-A1, secreted form: Secreted. Tissue Specificity: Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). Post-translational modifications: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. Similarity: Belongs to the ephrin family. Contains 1 ephrin RBD (ephrin receptor-binding) domain. Gene ID: 1942 Database links: Entrez Gene: 1942 Human Entrez Gene: 13636 Mouse Entrez Gene: 94268 Rat Omim: 191164 Human SwissProt: P20827 Human SwissProt: P52793 Mouse SwissProt: P97553 Rat Unigene: 516664 Human Unigene: 15675 Mouse Unigene: 8427 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内皮细胞受体蛋白酪氨酸激酶A/肿瘤坏死因子α诱导蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 神经生物学 激酶和磷酸酶 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid