粘附分子JAML蛋白抗体
规格：1mg/1ml
英文名： JAML
别名： adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule interacts with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; AMICA; Amica1; CRE
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human JAML
交叉反应：Human,
细胞定位：细胞膜
粘附分子JAML蛋白抗体产品介绍：background: JAML is a 394 amino acid single-pass type I membrane protein and novel adhesion molecule with localization at the cell plasma membrane in regions of cell-to-cell contact but not free cell borders, implying that JAML participates in homophilic interactions. JAML belongs to the immunoglobulin superfamily and is expressed in peripheral blood leukocytes, bone marrow, spleen, lymph nodes and fetal thymus, liver and spleen. JAML assists in the migration of leukocytes through endothelilal and epithelial tissues, mediates binding with CAR (coxsackie and adenovirus receptor) via its Ig-like V-type domain 2, and strengthens the binding of leukocytes to endothelial cells. Consisting of a transmembrane segment, cytoplasmic tail, 19-amino acid signal peptide and two extracellular immunoglobulin-like domains, JAML also undergoes alternative splicing resulting in three isoforms and is encoded by a gene mapping to human chromosome 11q23.3. Function: May粘附分子JAML蛋白抗体 function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Subcellular Location: Cell junction. Cell membrane. Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. Tissue Specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver粘附分子JAML蛋白抗体, spleen and thymus. Similarity: Belongs to the immunoglobulin superfamily. Contains 2 Ig-like V-type (immunoglobulin-like) domains. Gene ID: 120425 Database links: Entrez Gene: 120425 Human Entrez Gene: 270152 Mouse Entrez Gene: 315610 Rat Omim: *609770 Human SwissProt: Q86YT9 Human SwissProt: Q80UL9 Mouse Unigene: 16291 Human Unigene: 190461 Mouse Unigene: 21010 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粘附分子JAML蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞粘附分子 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid