MYRIP蛋白抗体
规格：1mg/1ml
英文名： MYRIP
别名： exophilin 8; exophilin; Exophilin-8; Exophilin8; Myosin VIIA and Rab interacting protein; Myosin-VIIa- and Rab-interacting protein; MyRIP; MYRIP_HUMAN; rab effector MYRIP; SLAC 2C; SLAC2 C; SLAC2-C; S
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYRIP/SL
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
MYRIP蛋白抗体产品介绍：background: Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, MYRIP蛋白抗体Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton. Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Subunit: Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4. Subcellular Location: Cytoplasm. In pre- and post-synaptic areas in photoreceptor cells and in the basal microvilli of retinal pigmentMYRIP蛋白抗体 epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. Tissue Specificity: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis. Similarity: Contains 1 FYVE-type zinc finger. Contains 1 RabBD (Rab-binding) domain. Database links: Entrez Gene: 25924 Human Entrez Gene: 245049 Mouse Entrez Gene: 360034 Rat Omim: 611790 Human SwissProt: Q8NFW9 Human SwissProt: Q8K3I4 Mouse SwissProt: Q7TNY7 Rat Unigene: 594535 Human Unigene: 100936 Mouse Unigene: 161974 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MYRIP蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid